Lithium Synergy contains lithium as lithium orotate — lithium bound to orotic acid for enhanced nutrient absorption and bioavailability. It is believed that some of the nutritional benefits of lithium come from its ability to support the synthesis and recycling of inositol, a primary component of the phosphoinositol signaling pathway. Research also shows that lithium supports the health and function of the hippocampus.* Lithium may also help support neurotransmitters and other factors that influence mood, behavior, and brain function.* The addition of vitamin B12 and trimethylglycine (TMG) to Lithium Synergy helps support healthy methylation pathways, and vitamin B12 is also needed for the synthesis of S-adenosyl-L.methionine (SAMe).